CBD goes through first-pass metabolism in the liver and its bioavailability can vary depending on who’s taking it, so we incorporate black seed oil in both our OG and Chill tinctures to support healthy liver functions and facilitate their bioavailability.
CBD has shown great promise in curbing drug cravings among those struggling with substance abuse, as well as improving sleep for people living with anxiety disorders.
Anxiety
CBD (Cannabidiol) is an all-natural plant extract, typically taken in capsule, tincture, oil or spray form. Additionally, it may be found in skin products, pet treats and food.
CBD can assist in relieving anxiety in various ways. By increasing serotonin levels and creating feelings of relaxation, it may ease symptoms. Furthermore, certain receptors in the brain may benefit from CBD’s therapeutic effect as it acts to alleviate its discomfort.
One study showed that participants given 300 milligrams of CBD prior to a public speaking test experienced less anxiety, possibly because it worked to inhibit activity in areas like the hippocampus and prefrontal cortex, where CBD acts on these two brain areas to lower activity.
CBD has been found to improve contextual fear conditioning extinction training and block reconsolidation of conditioned fear memories in rats, suggesting it may be an effective treatment for anxiety disorders. Furthermore, it shows promise in decreasing anticipatory arousal anxiety levels while supporting cognitive behavioral therapy outcomes.
Pain
CBD has been demonstrated to reduce chronic pain. A rat study concluded that CBD significantly decreased pain caused by peripheral neuropathy while simultaneously increasing pain sensitivity without impacting normal motor activity levels.
Studies on people with type 2 diabetes found that CBD oil products significantly reduced resistin levels while raising glucose-dependent insulinotropic peptide (GIP), an insulin regulator. This may help protect tissue damage due to high blood sugar.
CBD was shown to significantly enhance analgesia in a spared nerve injury neuropathic pain rat model by desensitizing spinal 5-HT1A receptors and inhibiting NMDA receptors, while attenuating mechanical allodynia and normalizing 5-HT activity; these effects could be counteracted with capsazepine and partially with WAY100635.
However, CBD should not be seen as an alternative to painkillers; you should consult your physician before trying new medicines like CBD. They will recommend an appropriate dosage and brand that adheres to GMP or is certified as dietary supplements by either U.S. Pharmacopoeia or Association of Official Agricultural Chemists.
Depression
Depression is a widespread mental health condition affecting individuals of all ages. Overcoming it can be a long and challenging battle; symptoms include constant low mood, emotional instability and fatigue as well as loss of interest in food or altered sleep patterns (insomnia/hypersomnia).
CBD has been proven to improve the mood of those using it to treat depression, but it should never replace current medication – rather, use alongside it and speak with your physician prior to making any sudden changes – particularly antidepressants as suddenly stopping can have adverse side effects.
One theory about how CBD helps depression is through its regulation of GABA neurotransmitter levels, which encourage neurons to stop firing. High stress levels can decrease GABA levels, contributing to anxiety and depression symptoms; CBD increases GABA levels to reduce these effects while helping sleep by decreasing cortisol levels and encouraging deeper levels of relaxation and restful restful slumber.
Sleep
Sleep is essential to our overall health and wellbeing. It aids memory formation, prevents sickness and keeps us alert – the recommended amount for adults is seven hours each night.
CBD has been proven to aid sleep patterns, especially among those suffering from insomnia. This may be because its relaxing qualities help alleviate anxiety levels without overstimulating.
Studies show that CBD can assist in alleviating insomnia by regulating sleep cycles, decreasing REM sleep duration and improving wakefulness during the day. Furthermore, its antidepressant and anxiolytic properties make it a potent remedy against anxiety that often contributes to chronic sleeping problems like insomnia.
When seeking to purchase CBD products to aid sleep, it’s essential that they have been independently tested for potency and purity. Look out for products with a Certificate of Analysis (COA), which shows a third-party laboratory has verified the contents.
