CBD oils have recently emerged as a trend in the health industry, providing low levels of tetrahydrocannabinol extracted from hemp plants – cousins of marijuana plants.
Epidiolex was approved by the Food and Drug Administration (FDA) to treat seizures caused by Lennox-Gastaut syndrome and Dravet syndrome in 2018. This approval has led to an explosion of interest for CBD products.
It Reduces Opioid Dependence
Cannabis acts by binding to cannabinoid receptors in the brain and may help ease opioid withdrawal symptoms, according to studies. Although less habit-forming than opioids, both can cause dependency over time if used regularly; more providers are becoming comfortable using cannabis to help their patients reduce or stop opioid usage.
Recent studies have demonstrated the efficacy of medicinal cannabis use to lower prescription opioid misuse. One such study concluded that states with legalised medicinal cannabis experienced a 25% drop in overdose mortality rates when compared to states without. These results demonstrate how medicinal cannabis could act as an effective alternative opioid replacement therapy for individuals struggling with opioid Use Disorder (OUD), thus potentially having huge public health implications.
It Boosts Your Digestive System
CBD has quickly become a rising health trend and can now be found everywhere from drinks to body lotions. According to studies, it may help relieve symptoms associated with irritable bowel syndrome such as cramping and diarrhea.
Workaround This drug acts by engaging the Endocannabinoid System (ECS) of your gut. This system of naturally-occurring cannabinoid receptors and cell signaling regulates gut function.
ECS activation reduces inflammation by modulating intestinal responses such as permeability and motility, while simultaneously strengthening brain-gut communication – which could help alleviate any associated stress related to digestive issues for people suffering from IBS. Furthermore, full spectrum CBD provides additional cannabinoids which enhance its impact on overall wellbeing.
It Regulates Pain
Recent discoveries reveal that cannabis’ analgesic properties do not result from reduced neural activity; rather, its effect is caused by changes in how pain signals are processed. The identification and cloning of cannabinoid receptors has made a considerable contribution towards this understanding.
Nociceptive neuronal firing correlates with behavioral antinociception following administration of the cannabinoid receptor agonist WIN 55,212-2 and is significantly inhibited by its antagonist, SR 141716A. Furthermore, electrically evoked acetylcholine release is reduced following administration of WIN and reversed following administration of SR 141716A.
CB1 receptors of spinal CBs increase nociceptive thresholds while decreasing nociception under hyperalgesic conditions such as formalin and CCI models. Furthermore, tonic activation of cannabinoid receptors may modulate both supraspinal and spinal noradrenergic and opioid systems by means of descending control.
It Reduces Psychotic Symptoms
At present, antipsychotic drugs carry significant side effects and do not work effectively for everyone presenting with psychotic symptoms; those considered at clinical high risk (CHR) must be monitored closely.
CBD is a non-psychotropic plant cannabinoid that may help to alleviate psychotic symptoms. It works as an allosteric modulator of CB1 and CB2 receptors, blocking their response to endogenous ligands; and may have other central actions which contribute to its antipsychotic effect; unlike amisulpride treatment with CBD was associated with reduced extrapyramidal symptoms, less weight gain, and prolactin increases that cause galactorrhoea or sexual dysfunction.
It Enhances Bone Regeneration
Studies indicate that the endocannabinoid system can have a direct influence on bone health, stimulating its formation by producing substances such as anandamide and 2-arachidonoyl glycerol that play key roles in remodeling and regulation of bones.
Studies conducted on mice reveal that CBD and cannabigerol (CBG) support bone fracture healing. Researchers originally intended to test these cannabinoids’ pain management capabilities; instead they discovered they also helped accelerate fracture repair processes.
Cannabinoids enhanced mesenchymal stem cell differentiation into osteoblasts – cells responsible for bone tissue formation. This increased differentiation accelerated bone formation while simultaneously strengthening it.
It Prevents Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic inflammatory disease that attacks joints such as knees, hips, hands, wrists and elbows. This painful inflammation often makes movement difficult while damaging cartilage and bone over time.
CBD, a nonpsychotropic phytocannabinoid found in cannabis, is an effective solution for arthritis pain relief. CBD works by binding to CB2 receptors on immune cells and decreasing their production of cytokines; additionally it increases intracellular calcium levels while inhibiting mitochondrial permeability transition pore opening.
Recent research uncovered the fact that 70% of patients suffering from rheumatic conditions used CBD oil to relieve their symptoms; this number may have been exaggerated due to selection bias.
